Remember this one? Wassuuuuuuuuuuuuuuuuuuuuuuuuuup…

Dunno if I can even call this one meme, since it’s maybe previous to the concept.

Also known as Whassup? or What’s up? and other variations.
I remember publishing a post about this Budweiser ad on my first blog, years ago.
And I posted several different versions… maybe ten or more versions if I remember correctly.
I think this ad campaign became famous before YouTube even existed… or it was among the first very famous YouTube videos.
Here are some of them (not shure if I’ll ever be able to remember all of them though):

Pizza Guy:

Wassabi:

Wassup – Dookie’s Girlfriend:

What are you doing:

Alien Wassup:

Grandmas:

’till here I think they are all “official”… the next ones are fanmade edits and tributes!

Wassup 2008 Obama campaign – VERY AWESOME! (notice they are the original wassup actors!):

Scary Movie Wassup:

Nintendo Wassup:

Simpsons edit:

Superfriends Wassup:

Transformers Wassup:

Grannies:

Kids:

Gah, enough!
Good times, good times.

Source: Gizmodo post and comments, plus some YouTube research.